Houston Methodist has signed a lease for 75,800 square feet of space at Dynamic One — the 355,000-square-foot building at TMC Helix Park in Houston. The lease represents the second major tenant at Dynamic One, following Baylor College of Medicine, which signed a lease for 114,000 square feet of lab and office space in early 2023.

Houston Methodist will utilize the space for its research initiatives with a focus on cardiovascular sciences, orthopedics and RNA therapeutics. The new space will accommodate two full floors of state-of-the-art biomedical research laboratories and will provide access to the amenities of the surrounding TMC Helix Park, including a multipurpose lounge and event space; an outdoor terrace; a fitness center; 24/7 security; additional lab storage; and oversized loading docks.

TMC Helix Park is a state-of-the-art life sciences hub that opened in October with the inaugural launch of the 250,000-square-foot TMC3 Collaborative building.

Developed by Beacon Capital Partners in partnership with Zoë Life Sciences, Dynamic One opened its doors in November.

“Beacon is proud to welcome Houston Methodist to Dynamic One at TMC Park, a state-of-the-art facility designed to enable and encourage leading life science and collaboration,” said Fred Siegel, president and CEO of Beacon Capital Partners.

“We are excited to welcome Houston Methodist to this space,” added William McKeon, president and CEO of the Texas Medical Center. “Their commitment to bench-to-bedside innovation and track record of transformative new discoveries aligns with our vision for the campus.”

Transwestern’s Eric Johnson, Lisa Bovermann and Kaitlyn Harp represented Beacon Capital Partners in lease negotiations, while Scott Carter of CBRE represented Houston Methodist

Houston’s Life Sciences Surge With Purpose-Built Real Estate

Beyond its lease at Dynamic One, Baylor College of Medicine also broke ground on a 503,000-square-foot, 11-story medical education and research facility adjacent to Helix Park in early 2023. This project — coupled with the TMC3 Collaborative building that launched in October 2023 — collectively accounted for a substantial portion of the four developments that saw Houston’s life sciences ecosystem to add nearly 1 million square feet of purpose-built laboratory space in the past year.

Other noteworthy expansions include the Alexander Estate Properties Woodlands — which encompasses 124,000 square feet — and Phase One of Levit Green, which spans 265,000 square feet.

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